OZMEN, OZGUR and KARA, DUYGU and UZLAS KARAMAN, EMINE and KARAKOC, FATMA and KARAKAYA, MUHAMMET AHMET and ARSLAN, ZAKIR (2016) Pheniramine Maleate is more effective than Lidocaine on Fentanyl Induced Cough. Pakistan Journal of Medical Sciences, 32 (3). ISSN 1681-715X
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Abstract
Objective: Fentanyl is frequently used during anesthesia induction. The use of fentanyl can cause cough through different mechanisms. Here, we aimed to investigate effects of pheniramine maleate (PM), an antihistaminic agent, and compare it with lidocaine on fentanyl induced cough.
Methods: This is a randomized double-blind prospective clinical study of ASA I-II, 120 patients scheduled for elective abdominal surgery. Patients were administered drugs intravenously and randomly allocated into three groups: Group C (2 ml 0.9 % normal saline), Group L (1mg/kg lidocaine), and Group F (PM 45.5 mg). 90 seconds after administration, 2µ/kg fentanyl was applied in three seconds to all patients. Severity of cough (mild: 1-2, moderate: 3-5, severe> 5), time of the cough and vital parameters were recorded 90 seconds after fentanyl injection.
Results: Eight patients (25%) in Group C had fentanyl induced cough whereas three patients (7.5%) in Group L and one patient (2.5%) in Group F experienced this phenomenon. There was statistically significant difference between Group F and Group C (p<0.05); however, differences between Group L and Group C or Group F and Group L were not statistically significant (p>0.05).
Conclusions: Pheniramine Maleate 45.5 mg is better that placebo and as effective as lidocaine to prevent fentanyl induced cough.
Item Type: | Article |
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Subjects: | Library Eprints > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 01 May 2023 04:56 |
Last Modified: | 13 Jul 2024 13:27 |
URI: | http://news.pacificarchive.com/id/eprint/1867 |