Chiesa, Irene and Ligorio, Cosimo and Bonatti, Amedeo F. and De Acutis, Aurora and Smith, Andrew M. and Saiani, Alberto and Vozzi, Giovanni and De Maria, Carmelo (2020) Modeling the Three-Dimensional Bioprinting Process of β-Sheet Self-Assembling Peptide Hydrogel Scaffolds. Frontiers in Medical Technology, 2. ISSN 2673-3129
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Abstract
Extrusion-based three-dimensional (3D) bioprinting is nowadays the most efficient additive manufacturing technology to fabricate well-defined and clinical-scale relevant 3D scaffolds, exploiting soft biomaterials. However, trial and error approaches are usually employed to achieve the desired structures, thus leading to a waste of time and material. In this work, we show the potential of finite element (FE) simulation in predicting the printability of a biomaterial, in terms of extrudability and scaffold mechanical stability over time. To this end, we firstly rheologically characterized a newly developed self-assembling peptide hydrogel (SAPH). Subsequently, we modeled both the extrusion process of the SAPHs and the stability over time of a 3D-bioprinted wood-pile scaffold. FE modeling revealed that the simulated SAPHs and printing setups led to a successful extrusion, within a range of shear stresses that are not detrimental for cells. Finally, we successfully 3D bioprinted human ear-shaped scaffolds with in vivo dimensions and several protrusion planes by bioplotting the SAPH into a poly(vinyl alcohol)–poly(vinyl pyrrolidone) copolymer, which was identified as a suitable bioprinting strategy by mechanical FE simulation.
Item Type: | Article |
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Subjects: | Library Eprints > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 25 Nov 2022 04:41 |
Last Modified: | 05 Aug 2024 06:04 |
URI: | http://news.pacificarchive.com/id/eprint/376 |