Kusne, Yael and Christiansen, Michael and Conley, Christopher and Gea-Banacloche, Juan and Sen, Ayan and Yegneswaran, Balaji (2021) Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic Disease. Case Reports in Critical Care, 2021. pp. 1-6. ISSN 2090-6420
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Abstract
Background. Hemophagocytic lymphohistiocytosis (HLH) was originally described in pediatric patients presenting with fever, hepatosplenomegaly, and blood cell abnormalities. Later, HLH was recognized to occur in adults, often associated with hematologic malignancies or serious infections. Conclusion. Patients presenting with HLH are critically ill, and rapid diagnosis is key. In adults, the search for the trigger must begin promptly as time to diagnosis effects survival. The underlying trigger in our patients was Histoplasma capsulatum infection, which is rare in the southwestern United States. Prompt diagnosis led to recovery in one patient, while the other did not survive.
Item Type: | Article |
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Subjects: | Library Eprints > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 26 Nov 2022 04:28 |
Last Modified: | 11 Jul 2024 04:50 |
URI: | http://news.pacificarchive.com/id/eprint/427 |