Impact of liver damage on the histoarchitectural profile of the cerebellar cortex in rats

Aim: This study described the histopathological profile of the cerebellar cortex and liver of rats with carbon tetrachloride (CCl4)-induced liver damage.

Methods: Male Wistar rats weighing about 250 g were divided into 2 groups (A and B). Group A (control) rats were treated with olive oil (OO) solution only while Group B rats were treated with carbon tetrachloride (CCl4) for 8 weeks. Thereafter, the cerebellum and liver of the rats were processed and stained with cresyl fast violet and H&E, respectively, for histopathological examinations of the cerebellar cortex and liver.

Result: Histopathological analysis shows cortical necrosis, uneven neuronal loss with varying range of vacuolations in the cerebellar cortices and moderate vascular congestion and extensive cytoplasmic damage on the hepatocytes of the CCl4 treated rats.

Conclusion: There is of loss of hepatic function in the CCl4 treated rats.