Seif, Sherif and Salama, Mai and Elsaeid, Ayman and Zaki, Aly and Badr, Seham (2022) Assessment of Primary Percutaneous Coronary Intervention Outcomes in Elderly and Very Elderly Patients. Journal of Advances in Medicine and Medical Research, 34 (19). pp. 113-124. ISSN 2456-8899
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Abstract
Background: To date, data regarding safety and efficacy of primary percutaneous coronary intervention (P-PCI) in elderly patients are scarce. We aimed to assess the outcomes of P-PCI in the elderly subgroup, and to evaluate whether the advantages of P-PCI diminish with advanced ages.
Methods: This retrospective study included elderly patients who underwent P-PCI for acute STEMI. Patients were sub grouped according to their age into three groups (Group A: aged 75-84, Group B: aged ³85 and control Group C: aged 65-74). The primary endpoint was in-hospital and 30-day all-cause mortality, and secondary endpoints were MACE (death, stroke, MI or re-PCI), stroke, vascular complication, bleeding and transfusion, target vessel re-intervention, contrast induced acute kidney injury (CI-AKI) and gastrointestinal (GI) bleeding.
Results: A total of 1111 patients were included with 339 patients in group A, 95 patients in group B and 677 patients in the control group C. In terms of the primary endpoint of our study, no significant difference could be detected between the studied groups. CI-AKI was the only secondary outcome to show a significant difference (P =0.005). Arterial hypertension and a previous history of chronic kidney disease (CKD) were independent predictors of in-hospital mortality, with OR 5.336, 95% CI 1.187 – 23.998 and OR 11.024, 95% CI 2.104 – 57.756, respectively. Additionally, final TIMI flow less than 3 (OR 42.322, 95% CI 5.674 – 315.667) and bleeding that required blood transfusion (OR 87.144, 95% CI 3.086 – 2460.628) showed higher risk of in-hospital MACE.
Conclusion: our study revealed that outcomes of P-PCI for STEMI in elderly population (³75) are favourable and comparable to younger patients. Therefore, P-PCI should be offered to every elderly patient presenting with acute STEMI, after considering risk factors for mortality and MACE in this special age group.
Item Type: | Article |
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Subjects: | Library Eprints > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 27 Jan 2023 05:20 |
Last Modified: | 11 Jul 2024 04:50 |
URI: | http://news.pacificarchive.com/id/eprint/633 |