Aref, Salah and El Agdar, Mohamed and Khaled, Nada and Ibrahim, Lamyaa and El-Ghonemy, Mohamed S. (2020) Clinical Impact of CD25/CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients. Advances in Hematology, 2020. pp. 1-5. ISSN 1687-9104
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Abstract
This study aimed to determine the clinical impact of CD25+/CD123+ coexpression in adult B-cell acute lymphoblastic leukemia (B-ALL) cases. One hundred and twenty newly diagnosed B-ALL patients (≤60 years old) were included in this study. CD123 and CD25 expression on leukemic blast cells were assessed using flow cytometry. CD25+/CD123+ coexpression was detected in 40/120 B-ALL patients (33.3%). All B-ALL patients showed CD25+/CD123+ coexpression had lower induction of remission response and shorter overall survival as compared to B-ALL cases lacking coexpression. In conclusion, CD25+/CD123+ positive coexpression is a reliable flow cytometry marker for prediction of the outcome of adult B-ALL patients and could be used as a novel parameter for risk stratification of adult B-ALL cases.
Item Type: | Article |
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Subjects: | Library Eprints > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 04 Apr 2023 04:51 |
Last Modified: | 22 Jul 2024 06:34 |
URI: | http://news.pacificarchive.com/id/eprint/760 |